Supplement reverses the characteristics of aging and promotes healthier aging

Supplement reverses the characteristics of aging and promotes healthier aging

New research has found that supplementing older people with GlyNAC — a combination of glycine and N-acetyl cysteine ​​— wards off several key indicators of aging and keeps people healthier as they age. Not only that, but older people also seemed fitter and stronger with slimmer waists after taking the GlyNAC supplement.

As reported in the Journals of Gerontology Series A, scientists at Baylor College of Medicine studied the effect of GlyNAC supplementation on 24 older adults and 12 younger people in a randomized, double-blind, human clinical trial.

At 16 weeks, GlyNAC supplementation was found to be associated with a wide range of benefits for key features of aging and age-related defects. This included oxidative stress, glutathione deficiency, mitochondrial dysfunction, mitophagy, inflammation, insulin resistance, endothelial dysfunction, genomic damage, stem cell fatigue and cellular aging. Meanwhile, no improvements were seen in those who received a placebo.

In turn, the older people who received doses of GlyNAC gained stronger muscles, lower blood pressure and smaller waist size. They were able to train harder and their walking speed improved, which is a surprisingly good indication of poor health in old age.

The researchers explain that the key to GlyNAC’s benefits lies in its ability to restore mitochondrial health and correct oxidative stress.

Mitochondria—the “powerhouse of the cell” as textbooks like to call it—generate most of the energy needed to fuel the cell’s biochemical reactions. However, as we age, they become less efficient at producing energy. As their previous mouse studies have suggested, this clinical trial showed that supplementation with GlyNAC appeared to elevate mitochondrial function in older people to levels found in young people.

As for oxidative stress, this describes the process by which the body is damaged by high levels of toxic waste products known as reactive oxygen species or free radicals, resulting in the breakdown of cells and DNA damage. Our bodies produce a natural antioxidant – glutathione – to counteract this, but its levels also decline as we age. The latest trial showed that supplementation with GlyNAC helps to remedy this glutathione deficiency and lowers oxidative stress in older people.

The GlyNAC supplementation was also found to have some real effects on the health and well-being of the participants. Older people who received GlyNAC experienced improvements in muscle strength and increased exercise capacity, as well as significant improvement in walking speed, which is known to be associated with increased survival rates in old people.

“One of the intriguing questions of this trial is why so many improvements are taking place toward promoting health. We believe this is due to the combined effort of three separate components – glycine, cysteine ​​(from NAC) and glutathione, not just glutathione itself. Glycine and cysteine ​​are both very important in their own right for cell health, and GlyNAC provides both,” said Dr. Rajagopal Sekhar, corresponding study author and professor of medicine at Baylor, in a statement. declaration.

“Glycine and cysteine ​​are building blocks to form glutathione, which also has health benefits. We believe the improvements in this trial and in our previous studies are a result of the combined effects of glycine and NAC and glutathione, and we call this combination the “Power of 3,” he added.

Despite how important the aging process is to everyone, scientists still know surprisingly little about how it unfolds. Through clinical trials like this, we can help unravel some of the mysteries and find ways to ensure that the world’s aging population lives happier and healthier lives.

“It is believed that correcting aging characteristics could help people age in a healthier way,” Sekhar added. “However, we do not fully understand why these aging features occur in the first place, and therefore there are no proven solutions through randomized human clinical trials to improve or correct aging features in aging people.”

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